Health information

Health A-Z

Your complete guide to conditions, symptoms and treatments, including what to do and when to get help.

Medicines A-Z

Find out how your medicine works, how and when to take it, possible side effects and answers to your common questions.

Coronavirus

Get the latest NHS information and advice about coronavirus (COVID-19).

NHS App

The NHS app lets you book appointments, order repeat prescriptions and access a range of other healthcare services.

NHS 111

NHS 111 online is a fast and convenient alternative to the 111 phone service and provides an option for people who want to access 111 digitally.

Find your NHS number

Use this service to get your NHS number.

Your NHS number is a 10 digit number, like 485 777 3456.

You do not need to know your NHS number to use NHS services, but it can be useful to have it.

Pregnancy

This guide includes all you need to know about trying for a baby, pregnancy, labour and birth.

Mental health and wellbeing

Find information and support for your mental health.

Social care and support

If you or someone you know needs help with day-to-day living because of illness or disability, this website explains your options and where you can get support.

RSV Vaccine

From 1 September 2024, those who turn 75 and those age 75 to 79 will be eligible for a free vaccine to protect them from respiratory syncytial virus (RSV).

RSV is an infectious disease of the airways and lungs. RSV infection often causes symptoms similar to a cold, including:

  • cough
  • sore throat
  • sneezing
  • a runny or blocked nose

It can also make you become wheezy or short of breath and lead to pneumonia and other life-threatening conditions. There is no specific treatment, and most infections will get better by themselves. Every year thousands of older adults need hospital care for RSV, and some of them will die. RSV can be more severe in people with medical conditions such as heart or lung disease or a weakened immune system.

RSV infection is common in young children but is most serious for small babies and for older people.

Oral HRT and GLP-1 Agonists

AQ: Oral HRT and GLP-1 Agonists (weight loss medication)

 

Q1. What are GLP-1 agonists?

GLP-1 agonists are medications such as tirzepatide and semaglutide, often known by brand names like Mounjaro, Ozempic, or Wegovy. They are prescribed for individuals with type 2 diabetes or to help with weight loss. These medicines work by slowing down the rate at which food leaves the stomach.

Q2: What is the concern regarding GLP-1 agonists and oral HRT?

Recent guidance suggests that GLP-1 agonist medications, such as Mounjaro, Wegovy, Ozempic, and Rybelsus, may reduce the absorption of oral progesterone, which is in some forms of HRT. This potential interaction is thought to be due to GLP-1 agonists slowing down gastric emptying. This could reduce protection of the womb lining (endometrium) and potentially increase the risk of abnormal bleeding and even endometrial cancer. 

Q3: Which oral HRT medications are affected?

Examples of HRT that could be affected include Progesterone (also known as Utrogestran or micronized progesterone), Norethisterone, and Medroxyprogesterone (also known as Provera).

Q4: What should I do if I am taking oral HRT and a GLP-1 agonist Mounjaro (tirzepatide), Wegovy (semaglutide), Ozempic (semaglutide), Saxenda (liraglutide)?

If you are taking oral HRT and Mounjaro, Wegovy, Ozempic, or Rybelsus please click CONTACT MY GP to complete an e-consult and the GP will  contact you.

 

 

Page last reviewed: 08 October 2026
Page created: 24 June 2024